Tametraline (CP-24,441) is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline.
Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is the S,S-isomer whereas tametraline is the 1R,4S-stereoisomer.
1R-Methylamino-4S-phenyl-tetralin is a potent inhibitor of norepinephrine uptake in rat brain synaptosomes, reverses reserpine induced hypothermia in mice, and blocks uptake of 3H-Norepinephrine into rat heart.
Tametraline is a norepinephrine–dopamine reuptake inhibitor.
Indatraline is an indanamine homolog of tetralin-based tametraline, although in the case of indatraline the product is pm-dichlorinated.
See also
- Cyproheptadine
- Dasotraline
- Desmethylsertraline
- EXP-561 (1-amino-4-phenylbicyclo[2.2.2]octane)
- JNJ-7925476
- Lometraline
- Nefopam
- Sertraline
References
